Cervical embryonal rhabdomyosarcoma: a case series from a single-institution

Abstract

Rhabdomyosarcoma is an aggressive malignant neoplasm that originates in the mesenchyme. It is the most frequent type of sarcoma in infants and children. Its localization in the uterus is extremely rare, and its incidence increase from 20 years-old onwards. Prognosis typically depends on the histological type, age, and the absence of metastasis. We present 5 cases of young females with a history of bleeding, a cervical tumor, whose biopsy was positive for embryonal rhabdomyosarcoma, botryoid variant. All patients received chemotherapy and surgery. Since rhabdomyosarcoma has a high rate of incidence in young women and its diagnosis in the cervix is less aggressive, conservative management of these cases is recommended fertility preservation. Post-surgical management should always consist of chemotherapy, as advances in this type of therapy have been shown to improve general survival rates. Hence, it is essential to report on rare tumors, as it helps in acquiring experience and appropriate knowledge for their clinical management and raises the need for further studies on this disease.